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Brian W. Fouty, M.D.

Brian W. Fouty, M.D.

Professor
Internal Medicine and Pharmacology

Biography

M.D.: University of Washington Medical School, Seattle
Post-doctoral: University of Arizona Health Sciences Center and University of Colorado Health Sciences Center

Research

The adult respiratory distress syndrome (ARDS) and acute lung injury (ALI) remain important clinical problems with mortality ranging from 30% to 50%. Recovery from ALI/ARDS requires repair of the disrupted capillary endothelial-alveolar epithelial barrier in the pulmonary microcirculation before proper gas exchange can be re-established.  Research in our lab examines the role of glucose and hypoxia in pulmonary vascular repair in vitro and in an animal model of acute lung injury in vivo.

Publications

Solodushko V, Fouty B. Terminal hairpins improve protein expression in IRES-initiated mRNA in the absence of a cap and polyadenylated tail. Gene Ther. 2023 Aug;30(7-8):620-627. doi: 10.1038/s41434-023-00391-4. Epub 2023 Feb 24. PMID: 36828937; PMCID: PMC9951143.

Olliff NS, Hunt MA, Paudel SS, Nguyen KN, Delcher HA, DeMeis JD, Roberts JT, Fouty BW, Audia JP, Kim JH, Borchert GM. Human YRNA 4 (HY4) plasma levels are a prognostic indicator of SARS-CoV-2 infection clinical severity. MicroPubl Biol. 2023 Aug 18;2023:10.17912/micropub.biology.000925. doi: 10.17912/micropub.biology.000925. PMID: 37662051; PMCID: PMC10474479.

Boyd A, Lochmaier P, Irelan D, Fiedler E, Lee JY, Fouty B, Abou Saleh L,
Richter W. Non-Selective PDE4 Inhibition Induces a Rapid and Transient Decrease of Serum Potassium in Mice. Biology (Basel). 2022 Oct 27;11(11):1582. doi: 10.3390/biology11111582. PMID: 36358283; PMCID: PMC9687940.

Lee JY, Stevens RP, Kash M, Alexeyev MF, Balczon R, Zhou C, Renema P, Koloteva A, Kozhukhar N, Pastukh V, Gwin MS, Voth S, deWeever A, Wagener BM, Pittet JF, Eslaamizaad Y, Siddiqui W, Nawaz T, Clarke C, Fouty BW, Audia JP, Alvarez DF, Stevens T. Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial Cell Survival during Infection. Am J Respir Cell Mol Biol. 2021 Dec;65(6):630-645. doi: 10.1165/rcmb.2020-0537OC. PMID: 34251286; PMCID: PMC8641799.

Rayner JO, Kim JH, Roberts RW, Wood RR, Fouty B, Solodushko V. Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection. Vaccines (Basel). 2021 Apr 2;9(4):345. doi: 10.3390/vaccines9040345. PMID: 33918409; PMCID: PMC8067036.

Abdalhadi H, Fahmawi Y, Das A, Fouty B. Life-Threatening Intrapulmonary Hemorrhage due to Vancomycin-Induced Thrombocytopenia: A Case Report. Case Rep Crit Care. 2020 Sep 30;2020:8890335. doi: 10.1155/2020/8890335. PMID: 33062342;
PMCID: PMC7545408.

Solodushko V, Bitko V, Barrington R, Fouty B. A DNA Vaccine in Which the RSV-F Ectodomain Is Covalently Linked to the Burkholderia pseudomallei Antigens TssM and Hcp1 Augments the Humoral and Cytotoxic Response in Mice. Front Immunol. 2019 Oct 11;10:2411. doi: 10.3389/fimmu.2019.02411. PMID: 31681300; PMCID: PMC6797551.

Troyanovsky B, Bitko V, Pastukh V, Fouty B, Solodushko V. The Functionality of Minimal PiggyBac Transposons in Mammalian Cells. Mol Ther Nucleic Acids. 2016 Oct 4;5(10):e369. doi: 10.1038/mtna.2016.76. PMID: 27701401; PMCID: PMC5095681.

Troyanovsky B, Bitko V, Fouty B, Solodushko V. Simple viral/minimal piggyBac hybrid vectors for stable production of self-inactivating gamma-retroviruses. BMC Res Notes. 2015 Aug 27;8:379. doi: 10.1186/s13104-015-1354-y. PMID: 26306622; PMCID: PMC4549879.